Author

A. C. Hurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:ecology & biodiversity· 2 Organism:human· 2 Assay:metagenomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. Wille· 5 shared M. Klaassen· 4 shared E. C. Holmes· 3 shared R. Farrukee· 3 shared B. J. Hoye· 2 shared I. G. Barr· 2 shared L. Y. Y. Lee· 2 shared M. Shi· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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5 shared papersMicrobiology

M. Wille

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

A new concept in antiviral drug design yields a potent influenza inhibitor

C. Mackenzie-Kludas, W.-Y. Wu, B. Jin, J. L. McKimm-Breschkin, E. L. Seah, P. Jones, E. Fairmaid, C. M. K. Tai, D. Y. Oh, P. Jenkins, A. C. Hurt, L. E. Brown

This paper introduces a new antiviral drug design approach that alters the virion surface microenvironment to block influenza virus entry, showing potent in vitro and in vivo activity.

bioRxiv · Nov 8, 2022 · PreprintMicrobiology

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

J. A. Belser, E. H. Lau, W. Barclay, I. G. Barr, H. Chen, R. A. Fouchier, M. Hatta, S. Herfst, Y. Kawaoka, S. S. Lakdawala, L. Y. Y. Lee, G. Neumann, M. Peiris, D. R. Perez, C. J. Russell, , K. M. Septer

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

bioRxiv · Apr 2, 2022Microbiology

Strong phylogenetic and ecological effects on host competency for avian influenza in Australian wild birds

M. Wille, S. Lisovski, D. Roshier, M. Ferenczi, B. J. Hoye, T. Leen, S. Warner, R. A. M. Fouchier, A. C. Hurt, E. C. Holmes, M. Klaassen

The paper examines host phylogeny and ecological factors influencing avian influenza susceptibility in Australian wild birds, finding phylogeny is a key driver of susceptibility.

bioRxiv · Feb 14, 2022Microbiology

Australia as a global sink for the genetic diversity of avian influenza A virus

M. Wille, V. Grillo, S. Ban de Gouvea Pedroso, G. W. Burgess, A. Crawley, C. Dickason, P. M. Hansbro, M. A. Hoque, P. F. Horwood, P. D. Kirkland, N. Y.-H. Kung, S. E. Lynch, S. Martin, M. McArthur, K. ORiley, , F. Y. K. Wong

This study shows Australia acts as a global sink for avian influenza A virus diversity, with isolated circulation and high reassortment, distinct from Northern Hemisphere patterns.

bioRxiv · Nov 30, 2021Evolutionary Biology

A novel and highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia

A. M. George, M. Wille, J. Wang, K. Anderson, S. Cohen, J. Moselen, L. Y. Y. Lee, W. W. Suen, J. Bingham, A. E. Dalziel, A. C. Hurt, D. T. Williams, Y.-M. Deng, I. G. Barr

This paper reports a novel, highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia, with less than 93% similarity to other lineages and vaccine strains.

bioRxiv · Nov 3, 2021Microbiology

Predicting potentially permissive substitutions that improve the fitness of A(H1N1)pdm09 viruses bearing the H275Y NA substitution

R. Farrukee, V. Gunalan, S. Maurer-Stroh, P. C. Reading, A. C. Hurt

This study predicts and validates permissive mutations that could restore fitness to oseltamivir-resistant A(H1N1)pdm09 viruses with the H275Y NA substitution.

bioRxiv · Mar 21, 2021 · PreprintMicrobiology

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

L. Y. Lee, J. Zhou, P. Koszalka, R. Frise, R. Farrukee, K. Baba, S. Miah, T. Shishido, M. Galiano, T. Hashimoto, S. Omoto, T. Uehara, E. Mifsud, N. Collinson, K. Kuhlbusch, , A. C. Hurt

The paper evaluates the fitness of baloxavir-resistant influenza A viruses in ferrets, finding reduced within-host fitness for A/H3N2 I38T and lower between-host fitness for A/H1N1pdm09 I38T compared to wild-type viruses.

bioRxiv · Sep 28, 2020Microbiology

Host age shapes virome abundance and diversity in birds

M. Wille, M. Shi, A. C. Hurt, M. Klaassen, E. Holmes

The paper examines how host age affects virome abundance and diversity in birds, finding higher viral diversity and abundance in juveniles compared to adults.

bioRxiv · Aug 23, 2020Microbiology

High levels of antibiotic resistance gene expression among birds living in a wastewater treatment plant

V. Rossetto Marcelino, M. Wille, A. C. Hurt, D. Gonzalez-Acuna, M. Klaassen, J.-S. Eden, M. Shi, J. R. Iredell, T. C. Sorrell, E. C. Holmes

The paper assesses antibiotic resistance gene expression in birds across different habitats, finding higher levels in wastewater treatment plant birds.

BMC Biology · Apr 8, 2019Peer-reviewedEcology

Characterization of influenza B virus variants with reduced neuraminidase inhibitor susceptibility

R. Farrukee, A. E. Zarebski, J. M. McCaw, J. D. Bloom, P. C. Reading, A. C. Hurt

This study characterizes two influenza B virus variants with NAI resistance, finding H273Y reduces fitness more than D197N in vivo, while D197N remains prevalent in surveillance.

bioRxiv · Sep 4, 2018Microbiology