Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-beta Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis
Y. Dong, B. Wang, M. Du, B. Zhu, K. Cui, S.-L. Chan, D. B. Cowan, S. Bhattacharjee, S. Wong, J. Bischoff, M. F. Linton, H. Chen
This study identifies epsins as promoters of endothelial-to-mesenchymal transition in atherosclerosis and shows that a therapeutic peptide targeting epsin-FGFR1 interaction reduces EndoMT and atherosclerosis progression.
bioRxiv · Aug 9, 2022 · PreprintCell Biology