Cell BiologybioRxiv
Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT
I. Al Khatib, J. Deng, Y. Lei…·T. Shutt
This study links TOP1MT deficiency and the P193L variant to mtDNA release and cGAS-STING activation, contributing to autoimmune disease susceptibility.
DOI 10.1093/hmg/ddad062