Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT
I. Al Khatib, J. Deng, Y. Lei, S. Torres-Odio, G. R. Rojas, L. E. Newman, B. K. Chung, S. A. Symes, H. Zhang, S.-y. N. Huang, Y. Pommier, A. Khan, G. S. Shadel, P. West, W. Gibson, T. Shutt
This study links TOP1MT deficiency and the P193L variant to mtDNA release and cGAS-STING activation, contributing to autoimmune disease susceptibility.
bioRxiv · Mar 8, 2022Cell Biology