Author

L. E. Newman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

G. R. Rojas· 2 shared G. S. Shadel· 2 shared A. Khan· 1 shared B. K. Chung· 1 shared C. G. Towers· 1 shared C. R. Schiavon· 1 shared D. A. Grotjahn· 1 shared H. Zhang· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

G. R. Rojas

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Author profile →

2 papers

Recent·Most cited

Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

L. E. Newman, N. Tadepalle, S. W. Novak, C. R. Schiavon, G. R. Rojas, J. A. Chevez, I. Lemersal, M. Medina, S. Rocha, C. G. Towers, D. A. Grotjahn, U. Manor, G. S. Shadel

The paper investigates how dysfunctional mitochondrial DNA is removed via an endosomal pathway, showing that defects in mtDNA replication and segregation trigger a fission checkpoint leading to immune activation and eventual disposal through RAB7-containing endosomes.

bioRxiv · Oct 12, 2022 · PreprintCell Biology

Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT

I. Al Khatib, J. Deng, Y. Lei, S. Torres-Odio, G. R. Rojas, L. E. Newman, B. K. Chung, S. A. Symes, H. Zhang, S.-y. N. Huang, Y. Pommier, A. Khan, G. S. Shadel, P. West, W. Gibson, T. Shutt

This study links TOP1MT deficiency and the P193L variant to mtDNA release and cGAS-STING activation, contributing to autoimmune disease susceptibility.

bioRxiv · Mar 8, 2022Cell Biology