Angiopoietin like protein 3 regulates low-density lipoprotein transport through aortic endothelial cells via endothelial lipase.
Yen Way Isabell Trinh, Grigorios Panteloglou, Evelina Voloviceva, Museer A. Lone, Stephanie Bernhard, Eveline Schlumpf, Kathrin Frey, Lucia Rohrer, Mary Juliette Melo Gonzales, Thomas A. Lutz, Saša Frank, Arnold von Eckardstein, Jérôme Robert
This study shows ANGPTL3 inhibits endothelial lipase-mediated LDL transport through aortic endothelial cells, which may explain mixed effects on ASCVD risk.
bioRxiv · Sep 30, 2025 · PreprintMolecular Biology