Jérôme Robert

The protein and lipid compositions of brain apolipoprotein E particles are cell type-specific

The paper identifies cell type-specific lipid and protein compositions of apoE lipoproteins secreted by different brain cell types and found in cerebrospinal fluid.

The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion

This study identifies COPI coatomer subunits that regulate LDL receptor activity, apoB secretion, and hepatic lipid storage, with genetic variants linked to elevated LDL-C levels.

Angiopoietin like protein 3 regulates low-density lipoprotein transport through aortic endothelial cells via endothelial lipase.

This study shows ANGPTL3 inhibits endothelial lipase-mediated LDL transport through aortic endothelial cells, which may explain mixed effects on ASCVD risk.

Both the low-density lipoprotein receptor and apolipoprotein E define blood-borne high-density lipoprotein entry into the brain.

The paper investigates how high-density lipoproteins (HDL) cross the blood-brain barrier, showing that LDLR and apoE composition determine HDL entry and brain localization.