Lucia Rohrer

The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion

This study identifies COPI coatomer subunits that regulate LDL receptor activity, apoB secretion, and hepatic lipid storage, with genetic variants linked to elevated LDL-C levels.

Angiopoietin like protein 3 regulates low-density lipoprotein transport through aortic endothelial cells via endothelial lipase.

This study shows ANGPTL3 inhibits endothelial lipase-mediated LDL transport through aortic endothelial cells, which may explain mixed effects on ASCVD risk.

Mapping the dynamic cell surface interactome of high-density lipoprotein reveals Aminopeptidase N as modulator of its endothelial uptake

The paper identifies a cell surface protein complex, the HDL synapse, that modulates HDL uptake into endothelial cells, with AMPN playing a key role.

Decoding functional high-density lipoprotein particle surfaceome interactions

The paper identifies HDL receptors and their interactions in human endothelial cells, revealing MERTK as a novel co-receptor for HDL binding and uptake.

Sensitive and reproducible determination of clinical HDL proteotypes

The paper develops a DIA-based proteotyping strategy for HDL particles, revealing significant proteotype differences between healthy individuals and those with T2DM or CHD.