Arnold von Eckardstein

The paper identifies cell type-specific lipid and protein compositions of apoE lipoproteins secreted by different brain cell types and found in cerebrospinal fluid.

This study identifies COPI coatomer subunits that regulate LDL receptor activity, apoB secretion, and hepatic lipid storage, with genetic variants linked to elevated LDL-C levels.

This study shows ANGPTL3 inhibits endothelial lipase-mediated LDL transport through aortic endothelial cells, which may explain mixed effects on ASCVD risk.

This study identifies SPTLC3's role in integrating bile acid-FXR signaling with sphingolipid remodeling in MASLD, showing its dysregulation in human liver and association with disease.

The paper investigates how high-density lipoproteins (HDL) cross the blood-brain barrier, showing that LDLR and apoE composition determine HDL entry and brain localization.

The paper identifies a cell surface protein complex, the HDL synapse, that modulates HDL uptake into endothelial cells, with AMPN playing a key role.

The paper identifies HDL receptors and their interactions in human endothelial cells, revealing MERTK as a novel co-receptor for HDL binding and uptake.

The paper develops a DIA-based proteotyping strategy for HDL particles, revealing significant proteotype differences between healthy individuals and those with T2DM or CHD.