Kathrin Frey

This study shows ANGPTL3 inhibits endothelial lipase-mediated LDL transport through aortic endothelial cells, which may explain mixed effects on ASCVD risk.

The paper identifies a cell surface protein complex, the HDL synapse, that modulates HDL uptake into endothelial cells, with AMPN playing a key role.

The paper identifies HDL receptors and their interactions in human endothelial cells, revealing MERTK as a novel co-receptor for HDL binding and uptake.

The paper develops a DIA-based proteotyping strategy for HDL particles, revealing significant proteotype differences between healthy individuals and those with T2DM or CHD.