Discovery and performance of DNA methylation panels for cancer detection and classification in blood
Gennady Margolin, Sara R. Bang-Christensen, Sara A. Grimm, Brian D. Bennett, Peter Kilfeather, Kevin Fedkenheuer, Sabina Pathan, Nichelle C. Whitlock, Peter A. Pinto, Leszek J. Klimczak, S. Katie Farney, Nader Jameel, Yun-Ching Chen, Hanna M. Petrykowska, Adam G. Sowalsky, , Laura L. Elnitski
This paper identifies DNA methylation biomarker panels for multi-cancer detection and tissue-of-origin classification using blood samples, achieving high sensitivity and low false positive rates.
bioRxiv · Sep 16, 2025 · PreprintCancer Biology