Author

Kevin Fedkenheuer

National Institutes of HealthORCID 0000-0003-2327-420XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Laura L. ElnitskiiD· 2 shared Adam G. SowalskyiD· 1 shared Brian D. BennettiD· 1 shared Catherine BaugheriD· 1 shared David O. HollandiD· 1 shared Gennady Margolin· 1 shared Hanna M. Petrykowska· 1 shared Hua TaniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Laura L. ElnitskiORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 16, 2025

Discovery and performance of DNA methylation panels for cancer detection and classification in blood

Gennady Margolin, Sara R. Bang-Christensen, Sara A. Grimm…·Laura L. Elnitski

This paper identifies DNA methylation biomarker panels for multi-cancer detection and tissue-of-origin classification using blood samples, achieving high sensitivity and low false positive rates.

DOI 10.1101/2025.09.16.676542

humanDNA methylation

𝕏 PostBluesky

GenomicsPLoS Computational BiologyPeer-reviewedMay 13, 2022

Characterization and clustering of kinase isoform expression in metastatic melanoma

David O. Holland, Valer Gotea, Kevin Fedkenheuer…·Laura L. Elnitski

The paper quantifies gene and isoform expression changes in metastatic melanoma compared to primary tumors, identifies distinct expression patterns linked to mutational subtypes, and highlights potential therapeutic targets.

7 citations

humanbulk RNA-seq

𝕏 PostBluesky