Feeding Schedule And Proteolysis Regulate Autophagic Clearance Of Mutant Huntingtin
Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels Henning Skotte, Yen T.N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi, Michael R. Hayden
This study shows that scheduled feeding and prevention of caspase-6 cleavage enhance autophagic clearance of mutant huntingtin in HD models and patients.
Acta Neuropathologica Communications · Feb 26, 2018Peer-reviewedNeuroscience