Functional Profiling of Single CRISPR/Cas9-Edited Human Long-Term Hematopoietic Stem Cells
Elvin Wagenblast, Maria Azkanaz, Sabrina A. Smith, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Joana Araújo, Leonard D. Shultz, Olga I. Gan, John Edgar Dick, Eric R. Lechman
The paper develops a method to efficiently edit LT-HSCs at single-cell resolution and demonstrates distinct functional outcomes of GATA1 editing.
Nature Communications · Oct 18, 2019Peer-reviewedGenetics