Author

Lorien Shakib

Cornell UniversityORCID 0000-0003-2502-2049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Aparna NathaniD· 1 shared Elvin WagenblastiD· 1 shared Eric R. LechmaniD· 1 shared Fan ZhangiD· 1 shared Gabriela KrivdovaiD· 1 shared Ilya KorsunskyiD· 1 shared Jessica I. BeynoriD· 1 shared Jessica L. McLeodiD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Aparna NathanORCID

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2 papers

Recent·Most cited

GenomicsGenome MedicinePeer-reviewedApr 20, 2021

IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation

Fan Zhang, Joseph Mears, Lorien Shakib…·Soumya Raychaudhuri

The paper identifies a common inflammatory macrophage phenotype across severe COVID-19 and other inflammatory diseases, driven by IFN-γ and TNF-α, and suggests potential therapeutic targets.

252 citationstop 1%

humanbulk RNA-seq

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GeneticsNature CommunicationsPeer-reviewedOct 18, 2019

Functional Profiling of Single CRISPR/Cas9-Edited Human Long-Term Hematopoietic Stem Cells

Elvin Wagenblast, Maria Azkanaz, Sabrina A. Smith…·Eric R. Lechman

The paper develops a method to efficiently edit LT-HSCs at single-cell resolution and demonstrates distinct functional outcomes of GATA1 editing.

49 citations

humanCRISPR screen

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