Author

Olga I. Gan

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1

Frequent Co-Authors

John Edgar DickiD· 3 shared Elvin WagenblastiD· 2 shared Eric R. LechmaniD· 2 shared Jessica L. McLeodiD· 2 shared Aarno V. PalotieiD· 1 shared Aitzkoa Lopez de Lapuente PortillaiD· 1 shared Aki Samuli HavulinnaiD· 1 shared Alexander G. BickiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenetics

John Edgar DickORCID

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Author profile →

3 papers

Recent·Most cited

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

Joana L. Araújo, Elvin Wagenblast, Véronique Voisin, Jessica L. McLeod, Olga I. Gan, Suraj Bansal, Liqing Jin, Amanda Mitchell, Blaise Gratton, Sarah K. Cutting, Andrea Arruda, Monica Doedens, Anthea Travas, Dennis Dong Hwan Kim, José‐Mario Capo‐Chichi, , John Edgar Dick

This study shows FLT3 is essential for ITD-mutated leukemic stem cells but not for normal hematopoietic stem cells, supporting targeted therapies for AML.

Blood · Jan 22, 2025Peer-reviewedCancer Biology

Functional Profiling of Single CRISPR/Cas9-Edited Human Long-Term Hematopoietic Stem Cells

Elvin Wagenblast, Maria Azkanaz, Sabrina A. Smith, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Joana Araújo, Leonard D. Shultz, Olga I. Gan, John Edgar Dick, Eric R. Lechman

The paper develops a method to efficiently edit LT-HSCs at single-cell resolution and demonstrates distinct functional outcomes of GATA1 editing.

Nature Communications · Oct 18, 2019Peer-reviewedGenetics

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

Erik L. Bao, Satish Kumar Nandakumar, Xiaotian Liao, Alexander G. Bick, Juha M Karjalainen, Marcin Tabaka, Olga I. Gan, Aki Samuli Havulinna, Tuomo Kiiskinen, Caleb A. Lareau, Aitzkoa Lopez de Lapuente Portilla, Bo Li, Connor A. Emdin, Veryan Codd, Christopher P. Nelson, , Vijay G. Sankaran

This study identifies 14 genome-wide significant loci and a polygenic signature for myeloproliferative neoplasms, implicating hematopoietic stem cell function and self-renewal in disease risk.

bioRxiv · Oct 8, 2019 · PreprintGenetics