Author

Jessica L. McLeod

University Health NetworkORCID 0009-0003-4669-5100Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

John Edgar DickiD· 3 shared Elvin WagenblastiD· 2 shared Eric R. LechmaniD· 2 shared Mark David MindeniD· 2 shared Olga I. Gan· 2 shared Sagi AbelsoniD· 2 shared Suraj BansaliD· 2 shared Aarushi GuptaiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

John Edgar DickORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedNov 11, 2025

Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy

Vincent Rondeau, Suraj Bansal, Marco M. Buttigieg…·Robert J. Vanner

This study shows that hematopoietic Tet2 inactivation improves immune checkpoint blockade response in mice and is associated with better clinical outcomes in melanoma patients with TET2-driven clonal hematopoiesis.

12 citationstop 3%

mousehuman

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Cancer BiologyBloodPeer-reviewedJan 22, 2025

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

Joana L. Araújo, Elvin Wagenblast, Véronique Voisin…·John Edgar Dick

This study shows FLT3 is essential for ITD-mutated leukemic stem cells but not for normal hematopoietic stem cells, supporting targeted therapies for AML.

11 citationstop 2%

humangenetic perturbation / CRISPR

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GeneticsNature CommunicationsPeer-reviewedOct 18, 2019

Functional Profiling of Single CRISPR/Cas9-Edited Human Long-Term Hematopoietic Stem Cells

Elvin Wagenblast, Maria Azkanaz, Sabrina A. Smith…·Eric R. Lechman

The paper develops a method to efficiently edit LT-HSCs at single-cell resolution and demonstrates distinct functional outcomes of GATA1 editing.

49 citations

humanCRISPR screen

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