Sabrina Ghadaouia

Telomeric dysfunction triggers an unstable growth arrest leading to irreparable genomic lesions and entry into cellular senescence

This study shows that telomere uncapping does not directly trigger senescence but leads to genomic instability through telomere fusions and DNA breaks, resulting in irreversible damage.

The NuA4 acetyltransferase and non-canonical chromatin-associated MRN/ATM activity temporally define senescence-associated secretory programs

The paper shows that delayed recruitment of acetyltransferases and non-canonical DDR activity temporally define SASP in senescence.