DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging
Motoshi Hayano, Jae-Hyun Yang, Michael S. Bonkowski, João A. Amorim, Jaime M. Ross, Giuseppe Coppotelli, Patrick T. Griffin, Yap Ching Chew, Wei Guo, Xiaojing Yang, Daniel L. Vera, Elias Salfati, Abhirup Das, Sachin Thakur, Alice E. Kane, , David A. Sinclair
The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.
bioRxiv · Oct 21, 2019 · PreprintMolecular Biology