Author

Jae-Hyun Yang

Harvard UniversityORCID 0000-0001-6122-4348Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Daniel L. VeraiD· 3 shared David A. SinclairiD· 3 shared Luis A. RajmaniD· 3 shared Bruce R. KsanderiD· 2 shared Elias SalfatiiD· 2 shared Margarita V. MeeriD· 2 shared Meredith S. Gregory-KsanderiD· 2 shared Michael S. BonkowskiiD· 2 shared

Activity by Year

2019-2019 · peak 3/yr

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10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Daniel L. VeraORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 21, 2019

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

Motoshi Hayano, Jae-Hyun Yang, Michael S. Bonkowski…·David A. Sinclair

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.

24 citations

mouseDNA methylation

𝕏 PostBluesky

Molecular BiologybioRxivPreprintOct 19, 2019

Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals

Jae-Hyun Yang, Patrick T. Griffin, Daniel L. Vera…·David A. Sinclair

The paper shows that inducing DNA breaks accelerates aging-related chromatin changes and loss of cell identity in mammals.

38 citations

mouseDNA methylation

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 31, 2019

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

Yuancheng Ryan Lu, Anitha Krishnan, Benedikt Brommer…·David A. Sinclair

This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.

20 citations

mouseDNA methylation

𝕏 PostBluesky