Opto-MDMi: a dual-lock optogenetic system for robust activation of endogenous p53
Tatsuki Tsuruoka, Takashi Sumikama, Sachiya Nakashima, Yuhei Goto, Kazuhiro Aoki
This paper introduces Opto-MDMi, a dual-lock optogenetic system that activates endogenous p53 with light, while suppressing basal activity in the dark.
bioRxiv · Apr 16, 2026 · PreprintSystems Biology