RFX3 is essential for the development and maturation of human pancreatic islets derived from pluripotent stem cells
Bushra Memon, Noura Aldous, Ahmed K. Elsayed, Sadaf Ijaz, Sikander Hayat, Essam Mohamed Abdelalim
This study investigates RFX3's role in human pancreatic islet development using iPSC-derived organoids, finding that RFX3 loss disrupts endocrine cell differentiation and beta-cell function.
bioRxiv · Sep 18, 2024 · PreprintDevelopmental Biology