Author

Ahmed Kamel Elsayed

Sidra Medical and Research CenterORCID 0000-0002-2519-1531Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Essam Mohamed AbdelalimiD· 2 shared Noura AldousiD· 2 shared Bushra MemoniD· 1 shared Nehad M. AlajeziD· 1 shared Sadaf Ijaz· 1 shared Sikander HayatiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersDevelopmental Biology

Essam Mohamed AbdelalimORCID

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2 papers

Recent·Most cited

Developmental BiologyStem Cell Reviews and ReportsPeer-reviewedJun 25, 2024

Identifying miRNA Signatures Associated with Pancreatic Islet Dysfunction in a FOXA2-Deficient iPSC Model

Ahmed Kamel Elsayed, Noura Aldous, Nehad M. Alajez, Essam Mohamed Abdelalim

The paper identifies miRNA signatures in FOXA2-deficient iPSC-derived pancreatic islets, showing altered miRNA-mRNA networks linked to diabetes and islet dysfunction.

1 citation

humanbulk RNA-seq

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Developmental BiologybioRxivPreprintMar 6, 2024

Deletion of RFX6, a Diabetes-Associated Gene, Impairs iPSC-Derived Islet Organoid Development and Survival, With No Impact on the Generation of PDX1+/NKX6.1+ Progenitors

Noura Aldous, Ahmed Kamel Elsayed, Bushra Memon…·Essam Mohamed Abdelalim

This study shows that RFX6 deletion in iPSCs impairs islet organoid development and survival through apoptosis and gene downregulation, without affecting PDX1+/NKX6.1+ progenitors.

DOI 10.1101/2024.03.06.583663

humanscRNA-seq

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