Noura Aldous

RFX3 is essential for the development and maturation of human pancreatic islets derived from pluripotent stem cells

This study investigates RFX3's role in human pancreatic islet development using iPSC-derived organoids, finding that RFX3 loss disrupts endocrine cell differentiation and beta-cell function.

Identifying miRNA Signatures Associated with Pancreatic Islet Dysfunction in a FOXA2-Deficient iPSC Model

The paper identifies miRNA signatures in FOXA2-deficient iPSC-derived pancreatic islets, showing altered miRNA-mRNA networks linked to diabetes and islet dysfunction.

Deletion of RFX6, a Diabetes-Associated Gene, Impairs iPSC-Derived Islet Organoid Development and Survival, With No Impact on the Generation of PDX1+/NKX6.1+ Progenitors

This study shows that RFX6 deletion in iPSCs impairs islet organoid development and survival through apoptosis and gene downregulation, without affecting PDX1+/NKX6.1+ progenitors.