Essam Mohamed Abdelalim

This study investigates RFX3's role in human pancreatic islet development using iPSC-derived organoids, finding that RFX3 loss disrupts endocrine cell differentiation and beta-cell function.

The paper identifies miRNA signatures in FOXA2-deficient iPSC-derived pancreatic islets, showing altered miRNA-mRNA networks linked to diabetes and islet dysfunction.

This study shows that RFX6 deletion in iPSCs impairs islet organoid development and survival through apoptosis and gene downregulation, without affecting PDX1+/NKX6.1+ progenitors.

This paper develops a scalable method using all-trans-retinoic acid to generate mesenchymal stem cells and adipocytes from human pluripotent stem cells with enhanced differentiation potential.