Atf4 protects islet beta-cell identity and function under acute glucose-induced stress but promotes beta-cell failure in the presence of free fatty acid
Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Mathew Dickerson, Prasanna K. Dadi, Yanwen Xu, Alan J. Simmons, Roland W. Stein, Christopher M. Adams, David Aaron Jacobson, Ken S. Lau, Qi Liu, Guoqiang Gu
This study shows Atf4 protects beta-cell function under high glucose but worsens beta-cell failure when combined with free fatty acids.
Diabetes · Feb 3, 2025Peer-reviewedGenetics