Ruiying Hu

Diabetes-associated MYT1 and MYT3 regulate human beta-cell insulin secretion and survival via other diabetes-risk genes

This study shows MYT1 and ST18 regulate human beta-cell survival and insulin secretion under normal and stress conditions, with their genes enriched for T2D-risk loci.

Deregulated Myt3 translation predisposes islet β-cells to dysfunction under obesity-induced metabolic stress

The paper shows that Myt3 translation is deregulated in β-cells under obesity-induced stress, leading to β-cell dysfunction and glucose intolerance.

Atf4 protects islet beta-cell identity and function under acute glucose-induced stress but promotes beta-cell failure in the presence of free fatty acid

This study shows Atf4 protects beta-cell function under high glucose but worsens beta-cell failure when combined with free fatty acids.

Pancreatic islet alpha cells regulate microtubule stability in neighboring beta cells to tune insulin secretion and induce functional heterogeneity in individual mouse and human islets

The paper shows that alpha cells regulate beta cell microtubule stability via Gcg and Glp1 signaling, affecting insulin secretion and creating functional heterogeneity in islets.

Myt Transcription Factors prevent stress-response gene over-activation to enable postnatal pancreatic β cell proliferation and function

This study shows that Myt transcription factors prevent over-activation of stress-response genes in pancreatic β cells, maintaining their function and survival.