Author

Christopher M. Adams

Mayo ClinicORCID 0000-0002-5795-7212Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Alan J. SimmonsiD· 1 shared Danni CheniD· 1 shared David Aaron JacobsoniD· 1 shared Fhujjen Barroga· 1 shared Guoqiang GuiD· 1 shared Ju CheniD· 1 shared Ken S. LauiD· 1 shared Mahircan Yagan· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Alan J. SimmonsORCID

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2 papers

Recent·Most cited

Transcriptional Readthrough at Atf4 Locus Suppresses Rps19bp1 and Impairs Heart Development

Zengming Zhang, Tongbin Wu, Zeyu Chen, Danni Chen, Zhengyu Liang, Christopher M. Adams, Yusu Gu, Mao Ye, Fhujjen Barroga, Sylvia Μ. Evans, Xiaohai Zhou, Ju Chen

The paper shows that cardiac defects in ATF4 knockout mice result from unintended Rps19bp1 downregulation due to transcriptional readthrough, not loss of ATF4 function.

Cardiovascular Research · Nov 14, 2025Peer-reviewedGenetics

Atf4 protects islet beta-cell identity and function under acute glucose-induced stress but promotes beta-cell failure in the presence of free fatty acid

Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Mathew Dickerson, Prasanna K. Dadi, Yanwen Xu, Alan J. Simmons, Roland W. Stein, Christopher M. Adams, David Aaron Jacobson, Ken S. Lau, Qi Liu, Guoqiang Gu

This study shows Atf4 protects beta-cell function under high glucose but worsens beta-cell failure when combined with free fatty acids.

Diabetes · Feb 3, 2025Peer-reviewedGenetics