Author

Sainan Chen

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

A. Stewart Campbell· 1 shared Aenne HarbertsiD· 1 shared Bernd SchnabliD· 1 shared Christopher J. OalmanniD· 1 shared Debanjan DhariD· 1 shared Jennifer T. Lau· 1 shared Jonah SimoniD· 1 shared Marcos F. FondevilaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Stewart Campbell

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1 paper

Recent·Most cited

Targeting Microbial Bile Salt Hydrolase Reprograms Bile Acid Metabolism and Ameliorates Metabolic Dysfunction-Associated Steatohepatitis in Mice

Wenchao Wei, Radka Graf, Yanhan Wang, Christopher J. Oalmann, Jennifer T. Lau, Xinyi Wang, Melanie Chien, Mary C. Conrad, Jonah Simon, Souradipta Ganguly, Tomoo Yamazaki, Aenne Harberts, Sainan Chen, Marcos F. Fondevila, Debanjan Dhar, , Bernd Schnabl

This study shows that the BSH inhibitor GR-7 reduces steatosis, inflammation, and fibrosis in a mouse model of MASH through bile acid metabolism reprogramming and immune modulation.

Molecular Metabolism · Aug 18, 2026Peer-reviewedPharmacology & Toxicology