Debanjan Dhar

This study shows that the BSH inhibitor GR-7 reduces steatosis, inflammation, and fibrosis in a mouse model of MASH through bile acid metabolism reprogramming and immune modulation.

This paper develops a mouse model of MASLD-associated HFpEF, showing mitochondrial dysfunction and cardiac plasticity, and demonstrates reversibility with dietary intervention.

The paper identifies TREM2-p53 signaling as a determinant of oxygen-induced lung injury in mice, showing that TREM2 loss reduces inflammation and improves lung development.