Tobias L. Lenz

Admixture as a source for HLA variation in Neolithic European farming communities

The paper examines HLA variation in Neolithic European farming communities, finding increased HLA diversity due to admixture with western hunter-gatherers, but lower diversity compared to modern populations.

Origin Matters: Using a Local Reference Genome Improves Measures in Population Genomics

This study shows that using a local reference genome improves mapping efficiency and genotyping accuracy in population genomics analyses of sticklebacks.

A microtubule associated protein is essential for malaria parasite transmission

This paper identifies a novel microtubule-associated protein, SPM3, essential for malaria parasite transmission by affecting gametocyte morphology and sporozoite motility.

Predicting Peptide HLA-II Presentation Using Immunopeptidomics, Transcriptomics and Deep Multimodal Learning

The paper develops PIA-M, a multimodal transformer-based tool for predicting HLA-II peptide presentation, achieving higher accuracy and faster runtime than existing methods.

A statistical genetics guide to identifying HLA alleles driving complex disease

This paper provides a statistical genetics guide for imputing HLA alleles from genotype data and offers best practices for association testing to identify HLA variants driving complex diseases.

VCF2Prot: An Efficient and Parallel Tool for Generating Personalized Proteomes from VCF Files

VCF2Prot generates personalized proteomes from VCF files by implementing a novel algorithm, improving runtime efficiency and enabling large-scale genomic-proteomic integration.

Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations

This study identifies shared and ethnicity-specific HLA associations with ulcerative colitis through trans-ethnic analysis of diverse populations.

HIV Peptidome-Wide Association Study Reveals Patient-Specific Epitope Repertoires Associated with HIV Control

This paper develops a peptidome-wide association study to identify HIV epitopes linked to viral load, revealing patient-specific epitope repertoires that explain HLA-related variation in HIV control.