PRMT1/Hmt1 drives α-synuclein aggregate dissolution through a catalysis-independent pathway
Sakshi Dewasthale, Purusharth I Rajyaguru
This study shows PRMT1/Hmt1 reduces α-synuclein aggregates and toxicity without requiring their methyltransferase activity, revealing a new pathway for protein quality control.
bioRxiv · Feb 28, 2026 · PreprintBiochemistry