Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20.
Anupriya Aggarwal, Samantha Ognenovska, Timothy Ison, Christina Fichter, Vanessa Milogiannakis, Madeeha Afzal, Alberto Ospina Stella, Shafagh A. Waters, Camille Esneau, Nathan Wylie Bartlett, Stefan Pöhlmann, Markus Hoffmann, Louise M. Burrell, Sheila K. Patel, Sally Ellis, , Stuart Grant Turville
This paper shows that SARS-CoV-2 Omicron lineages replicate using a specific ACE2 pool that does not complex with TMPRSS2, unlike pre-Omicron variants.
bioRxiv · Jul 7, 2025 · PreprintMicrobiology