Author

Timothy Ison

UNSW Sydney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander A. KhromykhiD· 2 shared Anthony Dominic KelleheriD· 2 shared Anupriya AggarwaliD· 2 shared Camille EsneauiD· 2 shared Cesar L. MorenoiD· 2 shared Christina FichteriD· 2 shared Fabienne BrilotiD· 2 shared G. Gregory NeelyiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Alexander A. KhromykhORCID

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2 papers

Recent·Most cited

Proteolytic control of the SARS-CoV-2 furin cleavage site defines the phenotypic evolution from the pandemic to endemic state

Anupriya Aggarwal, Samantha Ognenovska, Timothy Ison, Christina Fichter, Vanessa Milogiannakis, Madeeha Afzal, Alberto Ospina-Stella, Daniel Asarnow, Angelica L. Morgan, Shafagh A. Waters, Till Böcking, Boaz Ng, Camille Esneau, Nathan Bartlett, Atharva Naik, , Stuart Grant Turville

The paper shows how SARS-CoV-2 variants, particularly Omicron, evolved proteolytic controls at the Spike furin cleavage site to enhance transmission while reducing lower respiratory tract pathogenicity.

bioRxiv · Sep 24, 2026 · PreprintMicrobiology

Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20.

Anupriya Aggarwal, Samantha Ognenovska, Timothy Ison, Christina Fichter, Vanessa Milogiannakis, Madeeha Afzal, Alberto Ospina Stella, Shafagh A. Waters, Camille Esneau, Nathan Wylie Bartlett, Stefan Pöhlmann, Markus Hoffmann, Louise M. Burrell, Sheila K. Patel, Sally Ellis, , Stuart Grant Turville

This paper shows that SARS-CoV-2 Omicron lineages replicate using a specific ACE2 pool that does not complex with TMPRSS2, unlike pre-Omicron variants.

bioRxiv · Jul 7, 2025 · PreprintMicrobiology