STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm.
Sam Weeks, Dubravka Pezić, Martin Dodel, Kunal Shah, Amandeep Bhamra, Stephen R Henderson, Silvia Šurinová, Tyson V. Sharp, Faraz K. Mardakheh, Suzana Hadjur
This study shows STAG3 regulates post-transcriptional mRNA in mESCs, promoting exit from pluripotency by interacting with RNA-binding proteins and affecting mRNA stability.
bioRxiv · May 31, 2024 · PreprintCell Biology