Stephen R Henderson

Denaturing purifications support direct interaction between PRC2 and RNA in cells

The paper reanalyzes CLAP data to show PRC2 directly interacts with RNA in cells, correcting previous findings that missed this interaction due to a scaling step.

Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes

This study identifies epigenetic changes and accelerated ageing in multifocal small intestinal neuroendocrine tumours, revealing altered metabolic gene regulation and tumour-specific methylation patterns.

STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm.

This study shows STAG3 regulates post-transcriptional mRNA in mESCs, promoting exit from pluripotency by interacting with RNA-binding proteins and affecting mRNA stability.