Tyson V. Sharp

This study shows LIMD1 is essential for effective miRNA targeting and repression by AGO2, revealing its role in expanding miRNA regulatory capacity beyond conserved targets.

This study shows that C-terminal HaloTag fusion to AGO2 impairs its function and localization, highlighting the need to validate tagging strategies.

The paper shows that MSH6 regulates PD-L1 expression through SETD2 recruitment, and MSH6 KO cells have lower microsatellite instability despite higher mutational burden compared to MLH1 KO cells.

This study identifies CoAsy as a regulator of HIF signalling in TNBC, showing its loss stabilizes HIF-1 and HIF-2 and correlates with poor patient outcomes.

This study identifies GPX4 as a therapeutic target in LIMD1-deficient lung cancer by showing its role in ferroptosis susceptibility.

This study shows that LIMD1 loss in lung cancer increases PD-L1 expression, promoting immune evasion and enhancing response to immune checkpoint inhibitors.

This study shows STAG3 regulates post-transcriptional mRNA in mESCs, promoting exit from pluripotency by interacting with RNA-binding proteins and affecting mRNA stability.