Hampered AMPK-ULK1 cascade in Alzheimer disease (AD) instigates mitochondria dysfunctions and AD-related alterations that are alleviated by metformin
Arnaud Mary, Samantha Barale, Fanny Eysert, Audrey Valverde, Sandra Lacas‐Gervais, Charlotte Bauer, Sabiha Eddarkaoui, Luc Buée, Valérie Buée‐Scherrer, Frédéric Checler, Mounia Chami
This study shows that impairing the AMPK-ULK1 cascade in Alzheimer's disease leads to mitochondrial dysfunction and AD-related changes, which are improved by metformin treatment.
bioRxiv · Dec 28, 2024 · PreprintNeuroscience