Sandra Lacas‐Gervais

Loss of MTPAP disrupts mitochondrial RNA processing causing upregulation of type I interferon signalling

This study shows that MTPAP loss causes mitochondrial RNA processing defects, leading to type I interferon signaling upregulation through mt-dsRNA accumulation.

Human mammary 3D spheroid models uncover the role of filopodia in breaching the basement membrane to facilitate invasion

The paper uses 3D spheroid models to show filopodia-like protrusions help breast cancer cells invade by widening basement membrane pores.

Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions

This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.

Hampered AMPK-ULK1 cascade in Alzheimer disease (AD) instigates mitochondria dysfunctions and AD-related alterations that are alleviated by metformin

This study shows that impairing the AMPK-ULK1 cascade in Alzheimer's disease leads to mitochondrial dysfunction and AD-related changes, which are improved by metformin treatment.

Characterization of atypical BAR domain-containing proteins coded by Toxoplasma gondii

This study characterizes two atypical BAR domain-containing proteins in Toxoplasma gondii, revealing their distinct membrane-binding properties and roles in parasite trafficking.

MAFB drives differentiation by permitting WT1 binding to podocyte 1 specific promoters

The paper identifies MAFB's role in podocyte differentiation by enabling WT1 binding to specific promoters through chromatin accessibility.