Host response during unresolved urinary tract infection alters mammary tissue homeostasis through collagen deposition and TIMP1
Samantha Henry, Steven Macauley Lewis, Samantha L. Cyrill, Mackenzie Kate Callaway, Deeptiman Chatterjee, Amritha Varshini Hanasoge Somasundara, Gina Jones, Xue‐Yan He, Giuseppina Caligiuri, Michael Francis Ciccone, Isabella Andrea Diaz, Amelia Aumalika Biswas, Evelyn Hernández, Taehoon Ha, John Erby Wilkinson, , Camila O. dos Santos
This study shows that unresolved urinary tract infection leads to mammary tissue changes via collagen deposition and TIMP1, mediated by systemic host response.
bioRxiv · Feb 5, 2024 · PreprintDevelopmental Biology