David Arthur Tuveson

The paper identifies a MYC-USP39-SRSF1 regulatory axis in PDAC that stabilizes SRSF1 and promotes tumor progression, suggesting USP39 as a therapeutic target.

The paper identifies four epithelial transcription states in pancreatic cancer and links their origins to early developmental processes.

This study identifies FZD6 as a key driver of EMT and stromal remodeling in basal-like pancreatic cancer, downstream of SP1, with implications for therapeutic targeting.

This study shows pancreatic cancer cells secrete keratin-19 (KRT19) without a signal peptide by entering the ER via its head domain and through secretory autophagy, enabling CXCL12 capture to exclude T cells.

This study shows that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis in colorectal cancer, and inhibiting NET formation reduces necrosis and improves chemotherapy outcomes.

This study identifies FGFR2 as a key driver in early pancreatic tumorigenesis, showing that its inhibition can delay tumor formation and extend survival in mouse models.

This study identifies MARK2/3 as essential kinases for YAP/TAZ function in cancer and shows their inhibition can restore Hippo pathway tumor suppression.

This study shows that unresolved urinary tract infection leads to mammary tissue changes via collagen deposition and TIMP1, mediated by systemic host response.

This study develops a data synthesis framework to accurately infer genetic ancestry from cancer-derived molecular data across genomic platforms, showing high accuracy across different sequencing depths and modalities.