Somatostatin-positive Interneurons Contribute to Seizures in SCN8A Epileptic Encephalopathy
Eric R. Wengert, Raquel M. Miralles, Kyle C. A. Wedgwood, Pravin K. Wagley, Samantha M. Strohm, Payal S. Panchal, Abrar Majidi Idrissi, Ian C. Wenker, Jeremy A. Thompson, Ronald P. Gaykema, Manoj K. Patel
This study shows that somatostatin-positive interneurons with SCN8A mutations contribute to seizures by causing hyperexcitability and depolarization block.
Journal of Neuroscience · Sep 20, 2021Peer-reviewedNeuroscience