Targeting the 3' splice site by a decoy oligonucleotide attenuates U2AF1 splicing activity and inhibits leukemia
Carla Azar-Koussa, Marina Sakran, Efraim Rahamim, Anurag V Prabhu, Samar Salem, Adina R. Heinberg, Zahava Siegfried, Meital Ben-David-Naim, Eran Zimran, Erez Y. Levanon, Zvi Granot, Rotem Karni
This paper develops an RNA decoy strategy to inhibit splicing factor activity in leukemia, showing it reduces tumor burden in vivo regardless of spliceosomal mutations.
bioRxiv · Jul 7, 2026 · PreprintMolecular Biology