Erez Y. Levanon

AdarEdit predicts RNA editability using a structure-aware graph model trained on Alu duplexes across tissues and species, showing strong performance and evolutionary conservation.

The paper develops an in vitro method to study how guide RNAs affect RNA editing and splicing, finding that editing can both disrupt and improve splicing outcomes depending on the target site.

This paper develops an RNA decoy strategy to inhibit splicing factor activity in leukemia, showing it reduces tumor burden in vivo regardless of spliceosomal mutations.

The paper introduces the Cytoplasmic Editing Index (CEI) to quantify immune-relevant A-to-I RNA editing in cytoplasmic transcripts, showing improved sensitivity and specificity over global indices.

This study shows that inositol hexakisphosphate (IP6) is an essential cofactor for ADAR1 activity, with its depletion reducing RNA editing and supplementation restoring it.

This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.

This study identifies aberrant splicing caused by the NR2E3 c.932G>A mutation and shows that splice-shifting ASOs can restore full-length protein function.

This study shows that mutating APRT in turquoise killifish extends male lifespan and improves metabolic health, with mitochondrial function and AMPK activity playing key roles.

This paper introduces ROP to identify the source of unmapped RNA-Seq reads across diverse tissues, showing it can account for 99.9% of 1 trillion reads and reveals immune and microbial correlations.