Disease tolerant mice shelter a pathogenic intestinal microbiota able to trigger lethal disease in low tolerant hosts
Vinícius Mendes Vidal, Leticia Medeiros Ferreira, Bahtiyar Yılmaz, Elena Montes‐Cobos, Andreza M.D.S. Gama, Jamil Zola Kitoko, Samara G. Rosa, Gabriel A. Teixeira, José Nazioberto de Farias, Varsha Raghavan, Dan R. Littman, Heitor Siffert Pereira de Souza, Fábio B. Canto, Marcelo Torres Bozza
The paper shows that Mif-/- mice host a pathogenic microbiota that causes lethal disease in Il10-/- mice, revealing a mechanism of disease tolerance through microbiota transfer.
bioRxiv · Feb 20, 2025 · PreprintImmunology