Dan R. Littman

The paper identifies seed storage protein epitopes as targets of intestinal regulatory T cells that modulate immune responses to dietary antigens.

The paper shows that SFB colonization enhances anti-PD-1 therapy efficacy against antigen-sharing tumors by promoting T cell plasticity and immune control.

This study shows that cysteine restriction in mice causes rapid weight loss by depleting glutathione and coenzyme A, activating stress responses, and increasing lipolysis.

This study identifies Prdm16-dependent tolerogenic dendritic cells (tDC) that induce regulatory T cells to promote oral tolerance to food and microbiota antigens in mice and humans.

The paper shows that Mif-/- mice host a pathogenic microbiota that causes lethal disease in Il10-/- mice, revealing a mechanism of disease tolerance through microbiota transfer.

The paper investigates shared and distinct functional pathogenicity of gut microbiomes in inflammatory diseases using germ-free mice colonized with human fecal samples.

The paper characterizes antigen-specific CD8+ T cells post-SARS-CoV-2 vaccination and infection using multimodal sequencing, identifying unique biomarkers and clinical predictors.

The paper develops methods to infer transcriptional regulatory networks in Th17 cells using ATAC-seq and RNA-seq data, revealing new roles for transcription factors and their modules.