A Hidden Binding Pocket in the β- ketoacyl-ACP Synthase FabB
Ziran Jiang, Anika J. Friedman, Annette Thompson, Samuel J Andrzejewski, Kathryn M. Mains, Banumathi Sankaran, Michael D. Burkart, Michael R. Shirts, Jerome M. Fox
The paper identifies a hidden binding pocket in FabB that allows alternative acyl chain binding, contrasting with FabF's loss of long-chain binding upon mutation.
bioRxiv · Feb 28, 2026 · PreprintBiochemistry