Parkinson-associated SNCA enhancer variants revealed by open chromatin in mouse dopamine neurons
Sarah A. McClymont, Paul W. Hook, Alexandra I. Soto, Xylena Reed, William Law, Samuel J. Kerans, Eric L. Waite, Nicole Briceno, Joseph F. Thole, Michael G. Heckman, Nancy N. Diehl, Zbigniew K. Wszołek, Cedric D. Moore, Heng Zhu, Jennifer A. Akiyama, , Andrew S. McCallion
The paper identifies Parkinson's risk variants in a SNCA enhancer by analyzing open chromatin in mouse dopamine neurons and validates their function in zebrafish and mice.
The American Journal of Human Genetics · Nov 29, 2018Peer-reviewedGenetics