Author

William Law

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Genomics· 1

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Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Andrew S. McCallioniD· 4 shared Paul W. HookiD· 3 shared Sarah A. McClymontiD· 3 shared Eric L. WaiteiD· 2 shared A. Jennifer MortoniD· 1 shared Alexandra I. Soto· 1 shared Axel ViseliD· 1 shared Cedric D. MooreiD· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersGenetics

Andrew S. McCallionORCID

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4 papers

Recent·Most cited

Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons

Rachel J. Boyd, Sarah A. McClymont, Nelson B. Barrientos, Paul W. Hook, William Law, Rebecca J. Rose, Eric L. Waite, Jay K. Rathinavelu, Dimitrios Avramopoulos, Andrew S. McCallion

This study evaluates the mouse neural precursor cell line SN4741 as a proxy for midbrain dopaminergic neurons using genomic techniques and finds it lacks key dopaminergic markers and chromatin features.

BMC Genomics · Jun 7, 2023Peer-reviewedGenetics

Establishment of an eHAP1 Human Haploid Cell Line Hybrid Reference Genome Assembled from Short and Long Reads

William Law, René L. Warren, Andrew S. McCallion

The paper generates a high-quality hybrid reference genome for the eHAP1 haploid cell line using long and short reads, identifies structural variants, and highlights their potential regulatory impact.

Genomics · Jan 18, 2020Peer-reviewedGenomics

Parkinson-associated SNCA enhancer variants revealed by open chromatin in mouse dopamine neurons

Sarah A. McClymont, Paul W. Hook, Alexandra I. Soto, Xylena Reed, William Law, Samuel J. Kerans, Eric L. Waite, Nicole Briceno, Joseph F. Thole, Michael G. Heckman, Nancy N. Diehl, Zbigniew K. Wszołek, Cedric D. Moore, Heng Zhu, Jennifer A. Akiyama, , Andrew S. McCallion

The paper identifies Parkinson's risk variants in a SNCA enhancer by analyzing open chromatin in mouse dopamine neurons and validates their function in zebrafish and mice.

The American Journal of Human Genetics · Nov 29, 2018Peer-reviewedGenetics

Single-cell RNA-seq of mouse dopaminergic neurons informs candidate gene selection for sporadic Parkinson’s disease

Paul W. Hook, Sarah A. McClymont, Gabrielle Heather Cannon, William Law, A. Jennifer Morton, Loyal A. Goff, Andrew S. McCallion

The paper uses single-cell RNA-seq to identify candidate genes for sporadic Parkinson’s disease by comparing DA neuron subpopulations and integrating with GWAS data.

The American Journal of Human Genetics · Mar 1, 2018Peer-reviewedGenetics