IgG3 Hinge Architecture Expands Dengue Virus Breadth of A Quaternary Epitope Dependent Zika Virus Cross-Neutralizing Antibody
Sanjeev Kumar, Connor A. P. Scott, Lingling Xu, Kathryn M. Moore, Jacob W. Vander Velden, Samuel Shih, Richard H. West, Sneh Lata Gupta, Naphak Modhiran, Mehul S. Suthar, Daniel Watterson, Jens Wrammert
This study identifies an IgG3 subclass antibody that expands neutralization breadth against dengue and zika viruses by engaging a quaternary epitope through structural and functional analyses.
bioRxiv · Apr 29, 2026 · PreprintImmunology